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KMID : 0984720030350040221
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Infection and Chemotherapy
2003 Volume.35 No. 4 p.221 ~ p.225
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Disseminated Aspergillosis following Allogeneic Hematopoietic Stem Cell Transplantation in an Acute Leukemic Patient who was Previously Treated for Invasive Aspergillosis
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Bae Ki-Sun
Park Ji-Young
Shin Su-Youn
Mun Yeung-Chul
Choi Hee-Jung
Cho Min-Sun
Seong Chu-Myong
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Abstract
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Invasive aspergillosis has been increasing as the number of severe immunocompromised hosts rises. Particularly, in allogeneic hematopoietic stem cell transplantation (HSCT) recipients, incidence of invasive aspergillosis ranges from 4 to 10%. Even with appropriate treatment, the prognosis of invasive aspergillosis in allogeneic HSCT recipients remains poor, showing high mortality rate. Herein, we report a case where invasive aspergillosis in a patient with acute myelogeneous leukemia progressed to disseminated aspergillosis after allogenetic HSCT A 31-year-old woman with acute myelogenous leukemia had invasive aspergillosis after third reinductlon chemotherapy After administering amphotericin B, the patient underwent the wedge resection of lung, and HLA-matched allogeneic HSCT was then conducted. On day 14 of transplantation, the patient died of disseminated aspergillosis, including possible cerebritis and endocarditis despite the amphotericin B therapy.
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KEYWORD
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aspergillosis, leukemia, stem cell transplantation
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